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Results for 'genes'
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Research Highlights
An unusual switching mechanism that determines a single gene’s RNA output directly controls wound healing
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Sighting the genetic variants of eye diseases
27 February 2013Features & Innovations
In a world’s first, Singaporean scientists have discovered the genes responsible for cornea blindness, providing valuable information for treatment and prevention of degenerative eye diseases
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Medical genetics: The marker of resistance
01 August 2012Research Highlights
A genetic variation common in East Asian populations has been linked to cancer drug resistance
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Developmental biology: Off to a good start
01 August 2012Research Highlights
A protein thwarts developmental abnormalities by preventing removal of critical chemical marks from embryonic DNA
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Oncology: Understanding the culprit
20 June 2012Research Highlights
Study using a systems biology approach reveals how the transcription factor EVI1 contributes to cancer development and tumor invasion
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Medical genetics: Finding the elements of risk
11 April 2012Research Highlights
Genome-wide association studies reveal risk factors that increase the susceptibility of children to certain diseases
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Cancer biology: The two faces of a cancer signal
01 February 2012Research Highlights
A protein in breast cancer cells acts as a bidirectional switch to modulate inflammatory gene expression
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Immunology: Monocytes are not all the same
21 December 2011Research Highlights
Understanding the differences between various monocyte subtypes could aid diagnosis of blood disorders
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Dermatology: The twists and turns of tumor treatment
23 November 2011Research Highlights
A melanoma drug is linked to long-term changes in the tumor environment in a subset of tumors that respond effectively to the drug
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Molecular genetics: A collective effort
09 November 2011Research Highlights
Gene regulation may depend more on the synergy of multiple proteins rather than discrete contributions of individual factors
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Cancer biology: Aggravating tumor aggressiveness
12 October 2011Research Highlights
A protein secreted from breast cancer cells enhances the spread and survival of tumor cells
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Genetic engineering: Speeding up evolution
12 October 2011Research Highlights
Generating microbes with useful properties is quicker and easier if multiple genes are modified at the same time
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Medical genetics: More than skin deep
03 August 2011Research Highlights
Self-healing skin cancer and Loeys–Dietz syndrome are caused by mutations in the same gene
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Medical genetics: Hand and bone patterning gene
22 June 2011Research Highlights
The discovery of a rare genetic mutation sheds new light on bone and limb development
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Research Highlights
Efforts to understand a signaling factor’s contradictory behavior reveal a master switch for organ development
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Medical genetics: Many a little makes a mickle
10 November 2010Research Highlights
Genetic variations related to estrogen production have a cumulative effect on breast and endometrial cancer risk
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Oncology: A double whammy
27 October 2010Research Highlights
HPV18 puts women at a higher risk of developing cervical cancer because the virus converts a repressor of the cell cycle into an activator
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Metabolism: Another way to keep thin?
13 October 2010Research Highlights
A highly truncated receptor protein variant retains the ability to modulate metabolic activity in mice
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Cancer biology: Regulatory dysfunction spells trouble
29 September 2010Research Highlights
Discovery of the mechanism regulating the expression of an enzyme implicated in human cancer could open new avenues for treatment
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Stem cells: Driving differentiation
15 September 2010Research Highlights
Mysterious molecules called lncRNA direct the fate of stem cells in the early mouse embryo
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Cancer: Fine-tuning cellular suicide
23 June 2010Research Highlights
Increasing the efficacy and minimizing unwanted side effects of cancer gene therapy has been made possible using a new approach
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Development: Getting with the program
09 June 2010Research Highlights
Single-cell gene expression profiling reveals specific genetic programs underlying cell differentiation in pre-implantation mouse embryos
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Evolutionary genetics: Keeping cancer at bay
12 May 2010Research Highlights
Analysis of the genome of a primitive seafloor dweller shows that a well-known system for controlling DNA damage is highly conserved evolutionarily
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Genetics: Colitis research takes guts
14 April 2010Research Highlights
A large-scale genomic study identifies genes associated with bowel disease and provides clues to their functions
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Gene transfer: Stick-on protection
17 February 2010Research Highlights
A protective polymer shell enhances virus-mediated in vivo gene delivery
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Cancer biology: Protein stability’s dark side
03 February 2010Research Highlights
Stabilization of a tumor-inducing protein by the human papillomavirus protein E2 may be an early step in cervical tumor formation
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MicroRNA: Keeping death in check
20 January 2010Research Highlights
A small RNA molecule has a big influence on the activity of an important tumor suppressor
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Cancer biology: Finding patterns in repetition
20 January 2010Research Highlights
A sophisticated algorithm combines expression data with information about patient outcomes to reveal cancer genes
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Color vision: Evolution runs deep
20 January 2010Research Highlights
Elephant sharks display the potential for color vision despite mainly residing in deep waters
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Cancer biology: Breaking the cycle
06 January 2010Research Highlights
MicroRNA molecules represent an important regulatory roadblock preventing cancer cell proliferation
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Biochemistry: Finding the off switch
23 December 2009Research Highlights
Genetic evidence reveals that an enzyme that deactivates signaling pathways is associated with inflammation and cancer
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DNA detection: Color by nanoparticles
23 December 2009Research Highlights
Using a precise and fast nanoparticle-based technique, DNA detection by the naked eye is now possible
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A protein witnessing 30 years of evolution in cancer research
23 December 2009Features & Innovations
Cancer-suppressor protein p53 has undergone dramatic shifts in understanding over the past 30 years, but now scientists are entering a new era in the development of novel p53-based therapies.
Recent Highlights
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Jobs
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Postdoctoral Research Fellow - Singapore Bioimaging Consortium (SBIC)
Bioimaging in fluorescence or PET/SPECT/MRI
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HPC Software Analyst @ A*STAR Computational Resource Centre (A*CRC)
Institute of High Performance Computing, Fusionopolis, Singapore
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